"Often times it's just a memory error..."
UncleCheese, you nailed that one. I was able to get error reporting turned on and got the following:
Fatal error: Allowed memory size of 26214400 bytes exhausted (tried to allocate 35 bytes) in /SERVER PATH/sapphire/thirdparty/jsmin/JSMin.php on line 79
So the next question is how do I fix this?